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Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells
The interaction of the T cell surface glycoprotein CD8 with major histocompatibility complex (MHC) class I molecules on target cells is required for effective T cell activation. Mutations in the alpha 3 domain of the MHC class I molecule can disrupt binding to CD8, yet leave antigen presentation una...
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| Format: | Artigo |
|---|---|
| Język: | Inglês |
| Wydane: |
The Rockefeller University Press
1992
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2119298/ https://ncbi.nlm.nih.gov/pubmed/1613468 |
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