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Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells

The interaction of the T cell surface glycoprotein CD8 with major histocompatibility complex (MHC) class I molecules on target cells is required for effective T cell activation. Mutations in the alpha 3 domain of the MHC class I molecule can disrupt binding to CD8, yet leave antigen presentation una...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 1992
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2119298/
https://ncbi.nlm.nih.gov/pubmed/1613468
Tagiau: Ychwanegu Tag
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