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Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes
In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation s...
Guardat en:
| Format: | Artigo |
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| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
1991
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118971/ https://ncbi.nlm.nih.gov/pubmed/1655946 |
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