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Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes

In mice double transgenic for functionally rearranged T cell receptor (TCR) V beta 2 and V beta 8.2 genes we found that most T lymphocytes express both TCR beta chains simultaneously. These T cells show no abnormality in thymic selection in vivo and their TCRs are capable of transducing activation s...

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Bibliografiske detaljer
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1991
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118971/
https://ncbi.nlm.nih.gov/pubmed/1655946
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