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Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease

Cerebrovascular dysfunction contributes to the pathology and progression of Alzheimer's disease (AD), but the mechanisms are not completely understood. Using transgenic mouse models of AD (TgCRND8, PDAPP, and Tg2576), we evaluated blood–brain barrier damage and the role of fibrin and fibrinolys...

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Detalhes bibliográficos
Main Authors: Paul, Justin, Strickland, Sidney, Melchor, Jerry P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118680/
https://ncbi.nlm.nih.gov/pubmed/17664291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070304
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