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Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti–Tim-3 antibody in vivo

T cell immunoglobulin and mucin domain–containing molecule-3 (Tim-3) is a surface molecule that is preferentially expressed on activated Th1 cells in comparison to Th2 cells. Blockade of Tim-3 has been shown to enhance Th1-driven pathology in vivo, suggesting that blockade of Tim-3 may improve the d...

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Detalhes bibliográficos
Main Authors: Kearley, Jennifer, McMillan, Sarah J., Lloyd, Clare M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118608/
https://ncbi.nlm.nih.gov/pubmed/17517968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062093
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