Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

The deubiquitinating enzyme CYLD has recently been implicated in the regulation of signal transduction, but its physiological function and mechanism of action are still elusive. In this study, we show that CYLD plays a pivotal role in regulating T cell activation and homeostasis. T cells derived fro...

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Hlavní autoři: Reiley, William W., Jin, Wei, Lee, Andrew Joon, Wright, Ato, Wu, Xuefeng, Tewalt, Eric F., Leonard, Timothy O., Norbury, Christopher C., Fitzpatrick, Leo, Zhang, Minying, Sun, Shao-Cong
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118606/
https://ncbi.nlm.nih.gov/pubmed/17548520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062694
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