AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements

Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) class switch recombination and somatic hypermutation, and has also been implicated in translocations between Ig switch regions and c-Myc in plasma cell tumors in mice. We asked if AID is required for accelerated tumor de...

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Main Authors: Kovalchuk, Alexander L., duBois, Wendy, Mushinski, Elizabeth, McNeil, Nicole E., Hirt, Carsten, Qi, Chen-Feng, Li, Zhaoyang, Janz, Siegfried, Honjo, Tasuku, Muramatsu, Masamichi, Ried, Thomas, Behrens, Timothy, Potter, Michael
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118515/
https://ncbi.nlm.nih.gov/pubmed/17998390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070882
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