Different composition of the human and the mouse γδ T cell receptor explains different phenotypes of CD3γ and CD3δ immunodeficiencies

The γδ T cell receptor for antigen (TCR) comprises the clonotypic TCRγδ, the CD3 (CD3γε and/or CD3δε), and the ζζ dimers. γδ T cells do not develop in CD3γ-deficient mice, whereas human patients lacking CD3γ have abundant peripheral blood γδ T cells expressing high γδ TCR levels. In an attempt to id...

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Detalles Bibliográficos
Autores principales: Siegers, Gabrielle M., Swamy, Mahima, Fernández-Malavé, Edgar, Minguet, Susana, Rathmann, Sylvia, Guardo, Alberto C., Pérez-Flores, Verónica, Regueiro, Jose R., Alarcón, Balbino, Fisch, Paul, Schamel, Wolfgang W.A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2007
Materias:
Brief Definitive Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118495/
https://ncbi.nlm.nih.gov/pubmed/17923503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070782
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