Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals

Although required for many fundamental immune processes, ranging from self-tolerance to pathogen immunity, interleukin (IL)-2 production is transient, and the mechanisms underlying this brevity remain unclear. These studies reveal that helper T cell IL-2 production is limited by a classic negative f...

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Bibliographic Details
Main Authors: Villarino, Alejandro V., Tato, Cristina M., Stumhofer, Jason S., Yao, Zhengju, Cui, Yongzhi K., Hennighausen, Lothar, O'Shea, John J., Hunter, Christopher A.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2007
Subjects:
Brief Definitive Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118423/
https://ncbi.nlm.nih.gov/pubmed/17227909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061198
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