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Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis

T cells recognize protein antigens as short peptides processed and displayed by antigen-presenting cells. However, the mechanism of peptide selection is incompletely understood, and, consequently, the differences in the immunogenicity of protein antigens remain largely unpredictable and difficult to...

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Autori principali: Delamarre, Lélia, Couture, Rachael, Mellman, Ira, Trombetta, E. Sergio
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118388/
https://ncbi.nlm.nih.gov/pubmed/16908625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052442
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