Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromise...

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Detalhes bibliográficos
Main Authors: Khader, Shabaana A., Partida-Sanchez, Santiago, Bell, Guy, Jelley-Gibbs, Dawn M., Swain, Susan, Pearl, John E., Ghilardi, Nico, deSauvage, Frederic J., Lund, Frances E., Cooper, Andrea M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118335/
https://ncbi.nlm.nih.gov/pubmed/16818672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052545
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