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Yersinia pestis evades TLR4-dependent induction of IL12(p40)(2) by dendritic cells and subsequent cell migration

At the temperature of its flea-vector (~20–30°C) the causative agent of plague, Yersinia pestis, expresses a profile of genes distinct from those expressed in a mammalian host (37°C). When DC are exposed to Y. pestis grown at 26°C (Y. pestis-26°), they secrete copious amounts of IL-12p40 homodimer (...

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Detalhes bibliográficos
Main Authors: Robinson, Richard T., Khader, Shabaana A., Locksley, Richard M., Lien, Egil, Smiley, Stephen T., Cooper, Andrea M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640496/
https://ncbi.nlm.nih.gov/pubmed/18832714
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