Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity

Colitis involves immune cell–mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an epithelial ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model...

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Main Authors: Berruyer, Carole, Pouyet, Laurent, Millet, Virginie, Martin, Florent M., LeGoffic, Aude, Canonici, Alexandra, Garcia, Stéphane, Bagnis, Claude, Naquet, Philippe, Galland, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118186/
https://ncbi.nlm.nih.gov/pubmed/17145956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061640
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