Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

Carbon monoxide (CO), a byproduct of heme catabolism by heme oxygenase (HO), confers potent antiinflammatory effects. Here we demonstrate that CO derived from HO-1 inhibited Toll-like receptor (TLR) 2, 4, 5, and 9 signaling, but not TLR3-dependent signaling, in macrophages. Ligand-mediated receptor...

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Main Authors: Nakahira, Kiichi, Kim, Hong Pyo, Geng, Xue Hui, Nakao, Atsunori, Wang, Xue, Murase, Noriko, Drain, Peter F., Wang, Xiaomei, Sasidhar, Madhu, Nabel, Elizabeth G., Takahashi, Toru, Lukacs, Nicholas W., Ryter, Stefan W., Morita, Kiyoshi, Choi, Augustine M.K.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118097/
https://ncbi.nlm.nih.gov/pubmed/17000866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060845
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