Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

Carbon monoxide (CO), a byproduct of heme catabolism by heme oxygenase (HO), confers potent antiinflammatory effects. Here we demonstrate that CO derived from HO-1 inhibited Toll-like receptor (TLR) 2, 4, 5, and 9 signaling, but not TLR3-dependent signaling, in macrophages. Ligand-mediated receptor...

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Detalhes bibliográficos
Main Authors: Nakahira, Kiichi, Kim, Hong Pyo, Geng, Xue Hui, Nakao, Atsunori, Wang, Xue, Murase, Noriko, Drain, Peter F., Wang, Xiaomei, Sasidhar, Madhu, Nabel, Elizabeth G., Takahashi, Toru, Lukacs, Nicholas W., Ryter, Stefan W., Morita, Kiyoshi, Choi, Augustine M.K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118097/
https://ncbi.nlm.nih.gov/pubmed/17000866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060845
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