Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

Carbon monoxide (CO), a byproduct of heme catabolism by heme oxygenase (HO), confers potent antiinflammatory effects. Here we demonstrate that CO derived from HO-1 inhibited Toll-like receptor (TLR) 2, 4, 5, and 9 signaling, but not TLR3-dependent signaling, in macrophages. Ligand-mediated receptor...

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Autors principals: Nakahira, Kiichi, Kim, Hong Pyo, Geng, Xue Hui, Nakao, Atsunori, Wang, Xue, Murase, Noriko, Drain, Peter F., Wang, Xiaomei, Sasidhar, Madhu, Nabel, Elizabeth G., Takahashi, Toru, Lukacs, Nicholas W., Ryter, Stefan W., Morita, Kiyoshi, Choi, Augustine M.K.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118097/
https://ncbi.nlm.nih.gov/pubmed/17000866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060845
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