Determination of 17-dimethylaminoethylamino-17-demethoxygeldanamycin in human plasma by liquid chromatography with mass-spectrometric detection

An analytical method was developed and validated for the quantitative determination of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG; NSC707545), a novel heat shock 90 inhibitor, in human plasma. Calibration curves were linear in the concentration range of 1 to 500 ng/ml. Sample pretr...

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Bibliographic Details
Main Authors: Chen, Xiaohong, Gardner, Erin R., Gutierrez, Martin, Kummar, Shivaani, Figg, William D.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118051/
https://ncbi.nlm.nih.gov/pubmed/17851142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2007.08.022
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