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Tissue transglutaminase crosslinks ataxin-1: Possible role in SCA1 pathogenesis
Transglutaminase type 2 (TG2) has recently been implicated in crosslinking of mutant huntingtin protein into aggregates. Here we show that TG2 also crosslinks spinocerebellar ataxia-1 (SCA1) gene product ataxin-1. HeLa cell lysates expressing GFP tagged ataxin-1 with 2, 30 or 82 glutamines showed co...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2117902/ https://ncbi.nlm.nih.gov/pubmed/17045396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2006.08.003 |
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