Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34(+) cells

Sickle-cell disease (SCD) and β thalassemia constitute worldwide public health problems. New therapies, including hydroxyurea, have attempted to augment the synthesis of fetal hemoglobin (HbF) and improve current treatment. Lenalidomide and pomalidomide are members of a class of immunomodulators use...

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Autores principales: Moutouh-de Parseval, Laure A., Verhelle, Dominique, Glezer, Emilia, Jensen-Pergakes, Kristen, Ferguson, Gregory D., Corral, Laura G., Morris, Christopher L., Muller, George, Brady, Helen, Chan, Kyle
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2007
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117764/
https://ncbi.nlm.nih.gov/pubmed/18064299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32322
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