Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

Hepatocellular carcinoma (HCC) is the major primary malignant tumor in the human liver, but the molecular changes leading to liver cell transformation remain largely unknown. The Wnt-β-catenin pathway is activated in colon cancers and some melanoma cell lines, but has not yet been investigated in HC...

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Hlavní autoři: Coste, Alix de La, Romagnolo, Béatrice, Billuart, Pierre, Renard, Claire-Angélique, Buendia, Marie-Annick, Soubrane, Olivier, Fabre, Monique, Chelly, Jamel, Beldjord, Cherif, Kahn, Axel, Perret, Christine
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21165/
https://ncbi.nlm.nih.gov/pubmed/9671767
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