Rifampin and rpoB mutations can alter DNA supercoiling in Escherichia coli.

Two cases are described which indicate that RNA polymerase could alter DNA supercoiling. One occurred in a topA mutant in which abnormally high levels of plasmid supercoiling were lowered by rifampin, an inhibitor of the beta subunit of RNA polymerase. The second case involves suppression of a tempe...

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Detalles Bibliográficos

Publicado en:	J Bacteriol
Autores principales:	Drlica, K, Franco, R J, Steck, T R
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1988
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC211554/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2844734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.170.10.4983-4985.1988
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