Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSα

2-Hydroxyadenine (2-OH-A), a product of DNA oxidation, is a potential source of mutations. We investigated how representative DNA polymerases from the A, B and Y families dealt with 2-OH-A in primer extension experiments. A template 2-OH-A reduced the rate of incorporation by DNA polymerase α (Pol α...

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Autors principals: Barone, Flavia, McCulloch, Scott D., Macpherson, Peter, Maga, Giovanni, Yamada, Masami, Nohmi, Takehiko, Minoprio, Anna, Mazzei, Filomena, Kunkel, Thomas A., Karran, Peter, Bignami, Margherita
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2111060/
https://ncbi.nlm.nih.gov/pubmed/17188944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2006.11.002
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