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Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Exploration of the 1-Position

Modification of the C-1 ketone of salvinorin A (2a) produces analogues with opioid antagonist properties. Of particular significance is the finding that 1-deoxo-1,10-dehydrosalvinorin A (11a) is a moderately potent antagonist at all three opioid receptor subtypes, and that herkinorin (2b), a μ agoni...

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Bibliografische gegevens
Hoofdauteurs: Holden, Kenneth G., Tidgewell, Kevin, Marquam, Alfred, Rothman, Richard B., Navarro, Hernan, Prisinzano, Thomas E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2111044/
https://ncbi.nlm.nih.gov/pubmed/17904842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.09.050
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