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In vivo IL‐10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF‐β in the lung

BACKGROUD: Idiopathic pulmonary fibrosis is a devastating disorder for which there is no effective treatment. Transforming growth factor (TGF)‐β plays a critical role in provoking fibrosis. Interleukin (IL)‐10 is a potent immunosuppressive cytokine but its effect on the fibrosing process is unclear....

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Main Authors: Nakagome, K, Dohi, M, Okunishi, K, Tanaka, R, Miyazaki, J, Yamamoto, K
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMJ Group 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2104751/
https://ncbi.nlm.nih.gov/pubmed/16809410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thx.2005.056317
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