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A dual-kinase mechanism for Wnt coreceptor phosphorylation and activation
Signalling by the Wnt family of secreted lipoproteins plays essential roles in development and disease1. The canonical Wnt/β-catenin pathway requires a single-span transmembrane receptor, LDL receptor related protein 6 (LRP6)2-4, whose phosphorylation at multiple PPPSP motifs is induced upon Wnt sti...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2100418/ https://ncbi.nlm.nih.gov/pubmed/16341017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04185 |
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