Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2

The transcription factor Nrf2 regulates cellular redox homeostasis. Under basal conditions, Keap1 recruits Nrf2 into the Cul3-containing E3 ubiquitin ligase complex for ubiquitin conjugation and subsequent proteasomal degradation. Oxidative stress triggers activation of Nrf2 through inhibition of E3...

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Bibliographic Details
Main Authors: Sun, Zheng, Zhang, Shirley, Chan, Jefferson Y., Zhang, Donna D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099624/
https://ncbi.nlm.nih.gov/pubmed/17636022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00630-07
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