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In vitro screening for molecules that affect virus capsid assembly (and other protein association reactions)

Protein self-assembly is critical for numerous biological processes. Yet, assembly is rarely targeted by therapeutic agents, in part because it is hard to identify molecules that interfere with protein-protein interactions. Here we describe a simple fluorescence-based screen for self-association and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zlotnick, Adam, Lee, Angela, Bourne, Christina R, Johnson, Jennifer M, Domanico, Paul L, Stray, Stephen J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099249/
https://ncbi.nlm.nih.gov/pubmed/17406612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2007.60
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