Functional Defects of SKAP-55-Deficient T Cells Identify a Regulatory Role for the Adaptor in LFA-1 Adhesion

The ADAP-SKAP-55 module regulates T-cell receptor (TCR)-induced integrin clustering and adhesion in T cells. However, it has been unclear whether ADAP and/or SKAP-55 is an effector of the response. ADAP controls SKAP-55 expression such that ADAP(−)(/)(−) T cells are also deficient in SKAP-55 express...

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Bibliographic Details
Main Authors: Wang, Hongyan, Liu, Hebin, Lu, Yuning, Lovatt, Matt, Wei, Bin, Rudd, Christopher E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099233/
https://ncbi.nlm.nih.gov/pubmed/17646386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00556-07
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