Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA

Alternative lengthening of telomere (ALT) tumors maintain telomeres by a telomerase-independent mechanism and are characterized by a nuclear structure called the ALT-associated PML body (APB). TRF2 is a component of a telomeric DNA/protein complex called shelterin. However, TRF2 function in ALT cell...

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Detalhes bibliográficos
Main Authors: Stagno D'Alcontres, Martina, Mendez-Bermudez, Aaron, Foxon, Jennifer L., Royle, Nicola J., Salomoni, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099206/
https://ncbi.nlm.nih.gov/pubmed/18056407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200703020
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