Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres

Telomeres consist of TTAGGG repeats bound by protein complexes that serve to protect the natural end of linear chromosomes. Most cells maintain telomere repeat lengths by using the enzyme telomerase, although there are some cancer cells that use a telomerase-independent mechanism of telomere extensi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Loe, Taylor K., Li, Julia Su Zhou, Zhang, Yuxiang, Azeroglu, Benura, Boddy, Michael Nicholas, Denchi, Eros Lazzerini
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197349/
https://ncbi.nlm.nih.gov/pubmed/32217664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.333963.119
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