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An Activation Gating Switch in Kv1.2 Is Localized to a Threonine Residue in the S2-S3 Linker
The activation properties of Kv1.2 channels are highly variable, with reported half-activation (V(½)) values ranging from ∼−40 mV to ∼+30 mV. Here we show that this arises because Kv1.2 channels occupy two distinct gating modes (“fast” and “slow”). “Slow” gating (τ(act) = 90 ± 6 ms at +35 mV) was as...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2098734/ https://ncbi.nlm.nih.gov/pubmed/17766348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.116160 |
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