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Structural Basis of J Cochaperone Binding and Regulation of Hsp70

The many protein processing reactions of the ATP-hydrolyzing Hsp70s are regulated by J cochaperones, which contain J domains that stimulate Hsp70 ATPase activity and accessory domains that present protein substrates to Hsp70s. We report the structure of a J domain complexed with a J responsive porti...

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Detalhes bibliográficos
Main Authors: Jiang, Jianwen, Maes, E. Guy, Taylor, Alex B, Wang, Liping, Hinck, Andrew P, Lafer, Eileen M, Sousa, Rui
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096417/
https://ncbi.nlm.nih.gov/pubmed/17996706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.08.022
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