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Direct observation of the reversible unwinding of a single DNA molecule caused by the intercalation of ethidium bromide
Ethidium bromide (EtBr) is the conventional intercalator for visualizing DNA. Previous studies suggested that EtBr lengthens and unwinds double-stranded DNA (dsDNA). However, no one has observed the unwinding of a single dsDNA molecule during intercalation. We developed a simple method to observe th...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2095801/ https://ncbi.nlm.nih.gov/pubmed/17905818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm529 |
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