Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase

BACKGROUND AND PURPOSE: Rho-kinase (ROCK) has been implicated in the pathophysiology of altered vasoregulation leading to hypertension. Here we describe the pharmacological characterization of a potent, highly selective and orally active ROCK inhibitor, the derivative of a class of azaindoles, azain...

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Main Authors: Kast, R, Schirok, H, Figueroa-Pérez, S, Mittendorf, J, Gnoth, M J, Apeler, H, Lenz, J, Franz, J K, Knorr, A, Hütter, J, Lobell, M, Zimmermann, K, Münter, K, Augstein, K H, Ehmke, H, Stasch, J P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095102/
https://ncbi.nlm.nih.gov/pubmed/17934515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707484
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