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Mutations in the Δ7-sterol reductase gene in patients with the Smith–Lemli–Opitz syndrome

The Smith–Lemli–Opitz syndrome (SLOS) is an inborn disorder of sterol metabolism with characteristic congenital malformations and dysmorphias. All patients suffer from mental retardation. Here we identify the SLOS gene as a Δ7-sterol reductase (DHCR7, EC 1.3.1.21) required for the de novo biosynthes...

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Main Authors: Fitzky, Barbara U., Witsch-Baumgartner, Martina, Erdel, Martin, Lee, Joon No, Paik, Young-Ki, Glossmann, Hartmut, Utermann, Gerd, Moebius, Fabian F.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1998
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC20950/
https://ncbi.nlm.nih.gov/pubmed/9653161
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