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Role of protein kinase C-δ in the regulation of collagen gene expression in scleroderma fibroblasts

Working with cultured dermal fibroblasts derived from control individuals and patients with systemic sclerosis (SSc), we have examined the effects of protein kinase C-δ (PKC-δ) on type I collagen biosynthesis and steady-state levels of COL1A1 and COL3A1 mRNAs. Rottlerin, a specific inhibitor of PKC-...

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Udgivet i:J Clin Invest
Principais autores: Jimenez, Sergio A., Gaidarova, Svetlana, Saitta, Biagio, Sandorfi, Nora, Herrich, David J., Rosenbloom, Joan C., Kucich, Umberto, Abrams, William R., Rosenbloom, Joel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209435/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11696585/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12347
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