Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities

We developed a simple algorithm, i-Score (inhibitory-Score), to predict active siRNAs by applying a linear regression model to 2431 siRNAs. Our algorithm is exclusively comprised of nucleotide (nt) preferences at each position, and no other parameters are taken into account. Using a validation datas...

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Detalhes bibliográficos
Main Authors: Ichihara, Masatoshi, Murakumo, Yoshiki, Masuda, Akio, Matsuura, Toru, Asai, Naoya, Jijiwa, Mayumi, Ishida, Maki, Shinmi, Jun, Yatsuya, Hiroshi, Qiao, Shanlou, Takahashi, Masahide, Ohno, Kinji
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094068/
https://ncbi.nlm.nih.gov/pubmed/17884914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm699
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