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Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones

GRP94, an essential endoplasmic reticulum chaperone, is required for the conformational maturation of proteins destined for cell surface display or export. The extent to which GRP94 and its cytosolic paralog, Hsp90, share a common mechanism remains controversial. GRP94 has not been shown conclusivel...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dollins, D. Eric, Warren, Joshua J., Immormino, Robert M., Gewirth, Daniel T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094010/
https://ncbi.nlm.nih.gov/pubmed/17936703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.08.024
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