Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses

Fractalkine (FKN, CX3CL1) is a membrane-bound CX3C chemokine induced by primary proinflammatory signals in vascular endothelial cells (ECs). Here we examined the role of FKN in polarized Th1 or Th2 responses. Proinflammatory signals, including LPS, IL-1, TNF, and CD40 ligand, induced FKN, as did IFN...

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Pubblicato in:	J Clin Invest
Autori principali:	Fraticelli, Paolo, Sironi, Marina, Bianchi, Giancarlo, D’Ambrosio, Daniele, Albanesi, Cristina, Stoppacciaro, Antonella, Chieppa, Marcello, Allavena, Paola, Ruco, Luigi, Girolomoni, Giampiero, Sinigaglia, Francesco, Vecchi, Annunciata, Mantovani, Alberto
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209276/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11342581/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11517
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