Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses

Fractalkine (FKN, CX3CL1) is a membrane-bound CX3C chemokine induced by primary proinflammatory signals in vascular endothelial cells (ECs). Here we examined the role of FKN in polarized Th1 or Th2 responses. Proinflammatory signals, including LPS, IL-1, TNF, and CD40 ligand, induced FKN, as did IFN...

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Hauptverfasser: Fraticelli, Paolo, Sironi, Marina, Bianchi, Giancarlo, D’Ambrosio, Daniele, Albanesi, Cristina, Stoppacciaro, Antonella, Chieppa, Marcello, Allavena, Paola, Ruco, Luigi, Girolomoni, Giampiero, Sinigaglia, Francesco, Vecchi, Annunciata, Mantovani, Alberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2001
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC209276/
https://ncbi.nlm.nih.gov/pubmed/11342581
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