Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein

β-Secretase (BACE, Asp-2) is a transmembrane aspartic proteinase responsible for cleaving the amyloid precursor protein (APP) to generate the soluble ectodomain sAPPβ and its C-terminal fragment CTFβ. CTFβ is subsequently cleaved by γ-secretase to produce the neurotoxic/synaptotoxic amyloid-β peptid...

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Détails bibliographiques
Auteurs principaux: Cordy, Joanna M., Hussain, Ishrut, Dingwall, Colin, Hooper, Nigel M., Turner, Anthony J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2003
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC208827/
https://ncbi.nlm.nih.gov/pubmed/14504402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1635130100
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