Cytosol-endoplasmic reticulum interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila

Intracellular deposition of aggregated and ubiquitinated proteins is a prominent cytopathological feature of most neurodegenerative disorders frequently correlated with neural cell death. To elucidate mechanisms in neural cell death and degeneration, we characterized the Drosophila ortholog of Sec61...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Kanuka, Hirotaka, Kuranaga, Erina, Hiratou, Tetsuo, Igaki, Tatsushi, Nelson, Bryce, Okano, Hideyuki, Miura, Masayuki
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2003
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC208825/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14504396/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1934748100
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