Screening of gene function in cell intoxication by CNF1 links Sec61 translocon to Rac1 GTPase activity

ABSTRACT The CNF1 toxin from extraintestinal pathogenic Escherichia coli (ExPEC) deamidates glutamine 61 of Rac1 small GTPase, as well as its equivalents in RhoA and Cdc42 into glutamic acid. This post-translational modification of Rho proteins abrogates the hydrolysis of GTP into GDP, thereby enhan...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Eléa Paillares, Nathalie Deboosere, Stéphane Descorps-Declere, Maud Marechal, Daniel Gillet, Caroline Demangel, Amel Mettouchi, Priscille Brodin, Emmanuel Lemichez
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology 2025-11-01
Sarja:	mBio
Aiheet:	CNF1 toxin Rac1 Rho GTPases HACE1 Sec61 translocon mycolactone
Linkit:	https://journals.asm.org/doi/10.1128/mbio.02585-24
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