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Cytosol-endoplasmic reticulum interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila

Intracellular deposition of aggregated and ubiquitinated proteins is a prominent cytopathological feature of most neurodegenerative disorders frequently correlated with neural cell death. To elucidate mechanisms in neural cell death and degeneration, we characterized the Drosophila ortholog of Sec61...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kanuka, Hirotaka, Kuranaga, Erina, Hiratou, Tetsuo, Igaki, Tatsushi, Nelson, Bryce, Okano, Hideyuki, Miura, Masayuki
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC208825/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14504396/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1934748100
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