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The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
The p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers. The central role of p53 in response to stresses such as DNA damage, hypoxia, and oncogene activation underlies this high frequency of negative selection during tumorigenic transformation. Mutations in p53 disru...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC208795/ https://ncbi.nlm.nih.gov/pubmed/12972634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1934852100 |
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