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How protein thermodynamics and folding mechanisms are altered by the chaperonin cage: Molecular simulations

How the Escherichia coli GroEL/ES chaperonin assists folding of a substrate protein remains to be uncovered. Recently, it was suggested that confinement into the chaperonin cage itself can significantly accelerate folding of a substrate. Performing comprehensive molecular simulations of eight protei...

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Autors principals: Takagi, Fumiko, Koga, Nobuyasu, Takada, Shoji
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC208763/
https://ncbi.nlm.nih.gov/pubmed/12947041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1831920100
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