Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells

Homopurine (AG) and homopyrimidine (CT) oligodeoxyribonucleotides predicted to form triple-helical (triplex) structures have been shown to specifically suppress gene expression when supplied to cultured cells. Here we present evidence that homopurine RNA (effector) sequences designed to form a tripl...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Rininsland, Frauke, Johnson, Thomas R., Chernicky, Cheryl L., Schulze, Ekkehard, Burfeind, Peter, Ilan, Judith, Ilan, Joseph
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1997
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20870/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9159164/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.11.5854
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