Conditional activation defect of a human G(sα )mutant

Hormonal signals activate trimeric G proteins by promoting exchange of GTP for GDP bound to the G protein’s α subunit (Gα). Here we describe a point mutation that impairs this activation mechanism in the α subunit of G(s), producing an inherited disorder of hormone responsiveness. Biochemical analys...

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Detaylı Bibliyografya
Asıl Yazarlar: Iiri, Taroh, Farfel, Zvi, Bourne, Henry R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences of the USA 1997
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC20834/
https://ncbi.nlm.nih.gov/pubmed/9159128
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