Conditional activation defect of a human G(sα )mutant
Hormonal signals activate trimeric G proteins by promoting exchange of GTP for GDP bound to the G protein’s α subunit (Gα). Here we describe a point mutation that impairs this activation mechanism in the α subunit of G(s), producing an inherited disorder of hormone responsiveness. Biochemical analys...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20834/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9159128/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.11.5656 |
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