Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart

In the diabetic heart, chronic activation of the PPARα pathway drives excessive fatty acid (FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy. The related nuclear receptor, PPARβ/δ, is also highly expressed in the heart, yet its function has not been fully delineated...

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Bibliographic Details
Main Authors: Burkart, Eileen M., Sambandam, Nandakumar, Han, Xianlin, Gross, Richard W., Courtois, Michael, Gierasch, Carolyn M., Shoghi, Kooresh, Welch, Michael J., Kelly, Daniel P.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2082147/
https://ncbi.nlm.nih.gov/pubmed/18037994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32578
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