A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content

To explore the role of peroxisome proliferator-activated receptor α (PPARα)-mediated derangements in myocardial metabolism in the pathogenesis of diabetic cardiomyopathy, insulinopenic mice with PPARα deficiency (PPARα(−/−)) or cardiac-restricted overexpression [myosin heavy chain (MHC)-PPAR] were c...

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Hlavní autoři: Finck, Brian N., Han, Xianlin, Courtois, Michael, Aimond, Franck, Nerbonne, Jeanne M., Kovacs, Attila, Gross, Richard W., Kelly, Daniel P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC298755/
https://ncbi.nlm.nih.gov/pubmed/12552126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0336724100
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